Axol’s human iPSC-derived ventricular cardiomyocytes are manufactured at scale according to strict quality control standards using ISO 9001-accredited quality management systems, providing a continuous source of cells from the same genetic background for use in multiple experiments. This offers a physiologically relevant in vitro research model of human heart cells to reliably and repeatably test drug candidates for cardiotoxicity at scale.
With the advent of human iPSC-derived cardiomyocytes, the US Federal Food and Drug Administration Agency (FDA) launched a working group to assess the utility of these cells in reproducing cardiotoxicity in a dish, known as CiPA*. The assay tests cells with 28 compounds that are known to be cardiotoxic and induce the fatal arrhythmia “Torsades de Pointes”. Clyde Biosciences, a CRO that specializes in cardiotoxicity assays, used this assay to validate Axol’s cardiomyocytes for cardiac safety testing. Using these cells could help researchers to identify unsuitable drug candidates earlier in the drug discovery process and improve the number of promising pre-clinical drug candidates that translate through to clinical trials and to patients.